Speakers Analytical Solutions 2024
Seminar SAC DSP Workgroup
|
Maximilian J. Huber Function: PhD Student |
|
Centrifugal Field Flow Fractionation hyphenated with Raman Microspectroscopy: Size-resolved Chemical Analysis of Nanoplastics About the lecture The comprehensive physicochemical analysis of nanoplastics is of increasing importance to environmental scientists and toxicologists. Especially centrifugal field flow fractionation facilitates the analysis of complex mixtures and polydisperse samples due to its higher resolution compared to asymmetrical flow field flow fractionation. Chemical information is gained by vibrational (Raman) fingerprint spectra. A flow cell is used for the hyphenation which is enabled by single-beam optical trapping with the laser used for Raman spectroscopic analysis. Overall, hyphenation of field flow fractionation and Raman microspectroscopy allows for size-resolved chemical identification of mineral and plastic particles in the size range of 100 – 5000 nm. About the speaker M. Huber is a PhD student at the Institute of Water Chemistry at the Technical University of Munich in the Raman and SEM group headed by PD Dr. Natalia P. Ivleva. His research is focused on method development for nanoplastic analysis via field flow fractionation incl. combination with various detectors such as multi-angle light scattering, UV and Raman microspectroscopy. |
|
Dr. Laurens D. B. Mandemaker Function: Researcher |
|
Detection, characterization and model studies of nanoplastic particles About the lecture This talk will focus on nanoplastics; plastic particles smaller than 1µm in size. First, it will be addressed where they come from, and how we detect them in varying complex matrices. Then, micro-spectroscopic and mass-based techniques will be presented that can characterize small amounts and/or numbers of nanoplastics with large accuracy. Finally, some examples are shown of model studies on nanoplastics, and how they might behave towards organisms and/or human cells. About the speaker Laurens Mandemaker is a researcher at Utrecht University, both in the Institute of Sustainable and Circular Chemistry, and in the Institute for Risk Assessment Sciences, focusing on micro- and nanoplastics. Laurens did his PhD research in the group of Bert Weckhuysen, focusing on developing micro-spectroscopic techniques, such as AFM-IR, IR microscopy but also ToF-SIMS to catalytic thin film model systems. As a Postdoc, he applied this toolbox of techniques to the detection and characterization of nanoplastics. Since then, Laurens has been involved in several large European research initiatives to understand micro- and nanoplastics and their potential risk on (human) health and the environment. |
Ir. Laurine E.A. Yoe |
||
State-of-the-art characterization techniques for micro- and nanoplastics About the lecture About the speaker |
Dr. Ir. Linda de Poorter |
||
Microplastic release from outdoor exposed paint films: identification and quantification About the lecture About the speaker |
|
Maria Hayder
|
|
Towards simultaneous size determination and polymer identification of nanoplastics About the lecture About the speaker |
Prof. dr Marja Lamoree |
||
Quantitation of Micro and Nanoplastics in Human Blood by Pyrolysis-Gas Chromatography–Mass Spectrometry About the lecture About the speaker |
Seminar SAC CE Workgroup
Dr. Guinevere S.M. Lageveen-Kammeijer |
||
Exploring the Sweet Side of Cells by CE-MS About the lecture About the speaker |
Annika van der Zon |
||
Charge Variants Separation of Intact Monoclonal Antibodies at pH 5 using Nanoflow Sheath Liquid Capillary Electrophoresis-Mass Spectrometry About the lecture About the speaker |
Carlos Adelantado Sánchez, PhD Function: MSCA Postdoctoral Fellow |
||
Capillary electrophoresis as a promising technique towards a universal analytical tool for separation and detection of nanoplastic particles About the lecture About the speaker |
COAST Community of Innovation
Karen E. Schellens, MSc Function: Project leader |
||
Developing concepts for safe circular urban food systems About the lecture Large cities in the Netherlands have a big challenge. By 2030, nutrient losses from the agrifood system (-50%), and the use of fertilizers in agrifood production (-20%) must be reduced [1] while Member States must recycle or prepare at least 60% of their municipal waste for reuse [2]. However, biowastes may be contaminated with human pathogens, and in a full circular agrifood system persistent organic and/or inorganic chemical contaminants may accumulate in soil or food. Therefore, we aim to:
References: [1] The EU Green deal COM (2019) 640 final About the speaker |
Prof. Richard Schasfoort Function: Associate Professor at University of Twente |
||
Surface Protein Immunocoupling using Ramp Imaging Technology About the lecture Technologies for personalized and cost-effective diagnostic of infectious diseases can greatly enhance our quality of life. Here, a crucial aspect is the rapid and accurate quantification of biomolecular interactions (for example between proteins, viruses), for which Surface Plasmon Resonance imaging (SPRi) is a promising diagnostic tool. SPRi is a label-free, photonic-based technique carried out on biofunctionalized surfaces, used for investigation of biomolecular interactions. It generates thousands of datapoints because every camera pixel corresponds to an individual SPR sensor, while each datapoint generates a sensorgram that could be potentially used for highthroughput diagnostics. During the COVID-19 pandemic, researchers at UT and Interfluidics applied SPRi for realtime and label-free antibody screening of patients, measuring thousands of serum samples. It was found that a patient who will develop severe COVID-19 possesses high antibody concentrations in combination with overall worse quality of the antibodies (weak binding strength). However, such accurate measurements required a high level of expertise and time to extract and analyze the generated data, which hampers widespread use of this technology. To advance SPRi towards high-throughput and point-of-care applications, while decreasing analysis costs and facilitating its adoption in the clinics, novel functional materials and efficient analysis methods for SPRi are urgently needed. In SPIRIT, a new SPRi biosensing method will be developed towards dual measurement of concentration and binding strength of biomolecular interactions. We will i) develop protocols for smart coatings of SPRi substrates, ii) develop protocols for efficient data analysis, and iii) validate the method for diagnostics using a COVID-19 cohort. If successful, SPRi measurements will become “plugand- play”, paving the way for more accessible solutions for personalized diagnostics. |
Cas Damen Function: Professor (Lector) |
||
Observed – detecting veterinary disease by odour profiles
About the lecture Within the NWA-ORC project OBSeRVeD, a broad consortium is working towards a cheap, low-power and smart very sensitive VOC sensor platform, based on micro- or nanotechnology for making it sufficiently sensitive and scalable, coated with affinity layers.
About the speaker Cas Damen obtained his PhD from the University of Twente under the supervision of Dave Blank and Horst Rogalla in the field of High-Temperature superconductors. Damen is co-founder of Twente Solid State Technology BV, a company specialized in thin layer deposition equipment and currently part of Demcon Holding. Since 1 March 2014, Cas Damen has been appointed professor in Applied Nanotechnology at Saxion University of Applied Sciences in Enschede. Within his research group, research is being conducted into the implementation of chip technology (with a focus on photonic sensor devices) for medical, environmental and food safety applications. |
Seminar KNCV MCT
Willie Peijnenburg Function: Professor at the Institute of Environmental Sciences (CML) and senior researcher at the RIVM Company: RIVM/CML |
||
Nano and microplastics in the environment About the speaker Prof. Dr. Willie Peijnenburg is Professor at the Institute of Environmental Sciences (CML) of the Faculty of Science of Leiden University, Leiden (The Netherlands), chair position “Environmental Toxicology and Biodiversity”, and senior researcher at the National Institute of Public Health and the Environment (RIVM), Bilthoven (The Netherlands). He obtained his PhD at the Eindhoven University of Technology (The Netherlands) on photochemical transformations of organic chemicals and he currently is involved in research aimed at underpinning the risk assessment of chemical substances, amongst others dealing with the processes at the interface of environmental chemistry and toxicity in aquatic and terrestrial environments. Current research topics include nanoparticle and microplastics related research, fate assessment, dosimetry, transformation/dissolution, impact of water composition on fate of chemicals. Apart from research he is also involved in the risk assessment of chemicals according to REACH. He has published over 450 scientific papers. |
Bjorn Berendsen Function: Program Manager Food Safety |
||
Total PFAS analyses , what can we learn?
About the lecture The occurrence of PFAS in the environment and food products is a potentially urgent (one) health concern and is currently getting a lot of attention in the media and society. Besides understanding the toxicological impact of PFAS, also exposure monitoring is required to indicate the impact of these substances. Such monitoring comes with enormous challenges. First, the safe total weekly intake for a small selection of PFAS is currently set at 4.4 nanograms per kilogram of body weight per week by EFSA. This requires the detection of low ppt levels of PFAS in difficult matrices like food products. Second, depending on the definition, over 15.000 PFAS exist according to the U.S. Environmental Protection Agency. As currently the toxicological impact of most of these PFAS is unknow, all of them could be relevant for exposure assessment. Clearly, PFAS analysis is a currently urgent analytical challenge and multiple analytical techniques are required to meet the research needs. At Wageningen Food Safety Research, we have developed and implemented several analytical techniques, that together contribute to the PFAS challenge. In this lecture we report the mass balance approach that includes a total PFAS analysis using the Total Oxidizable Precursor Assay or Combustion Ion Chromatography together with targeted PFAS analysis using LC-MS/MS with low ppt detection limits. Briefly the potential follow-up by LC-HRMS to detect and (tentatively) identify other PFAS to try to map the complete PFAS space in complex matrices is demonstrated.
About the speaker Bjorn Berendsen studied Analytical Chemistry at Amsterdam University and did his PhD at Wageningen University whilst being affiliated to Wageningen Food Safety Research (WFSR, part of WUR). He is an expert in residue analysis of mainly veterinary drugs and perfluoro alkyl substances in food and environmental matrices and ran several projects on food safety risks in the circular biobased economy. He has been working at WFSR for 25 years in several functions and is currently, besides researcher and project manager, the program manager of the statutory tasks policy research program and as such part of the institute's management team. |
Dr. E.D. (Elvio) Amato Function: Researcher - Chemical Water Quality and Health |
||
Analytical tools for monitoring PFAS in water
About the lecture Per- and polyfluoroalkyl substances (PFAS) are a very broad and diverse group of chemicals that pose a risk to human health and the environment. According to the Organisation for Economic Co-operation and Development (OECD), PFAS include over 4700 compounds, however, less than 40 PFAS are routinely monitored in environmental samples. While not all known PFAS are expected to be environmentally relevant, there is a (regulatory) need to monitor a more representative fraction of PFAS than the relatively few compounds routinely assessed. In this presentation, we dive into the PFAS chemical space and explore different methods and techniques useful for the assessment of PFAS that are typically not included in routine monitoring programmes, with a particular focus on suspect and non-targeted screening (NTS) by means of liquid chromatography – high-resolution mass spectrometry (LC-HRMS), and total oxidizable precursors (TOP) assay. These methods allow to investigate a broader range of PFAS and are currently considered for inclusion in European regulations. The pros and cons of these different techniques, and their applications in the water sector, are critically discussed.
About the speaker Elvio Amato works as a scientific researcher at the KWR Water Research Institute (The Netherlands). He attained his PhD in Environmental Chemistry from the University of Wollongong (Australia) and worked as a postdoctoral researcher at the University of Antwerp (Belgium). He focused on the assessment of contaminants bioavailability in water, including inorganic and organic substances, and the application of novel sampling techniques. His current research interests include investigating the occurrence and behavior of emerging contaminants in the environment, with a strong focus on drinking water sources. |
Viktoriia Turkina Function: PhD candidate |
||
Can we know more about unknowns?
About the lecture Complex environmental samples contain numerous known and unknown constituents. LC-HRMS Non-Targeted Analysis has proven indispensable for the comprehensive analysis of such samples. However, the challenge of identifying these constituents remains a major bottleneck. To address this, we are developing a prioritization strategy that focuses on the most relevant features based on aquatic toxicity categories, as well as fragmentation and chromatographic information of unknown features. Therefore, instead of identifying each feature, we directly describe their activity. We're constructing two models: a Random Forest classification model to assign toxicity categories based on fragmentation data, and kernel density estimation to determine the probability of features belonging to specific toxicity classes. These algorithms allow us to characterize unknown features at both the MS2 and chromatographic level.
About the speaker Viktoriia Turkina is a PhD candidate in the group of Saer Samanipour (HIMS, Analytical Chemistry Group, EMCMS. Her background is in Analytical Chemistry for industrial analysis. In her PhD, she is focusing on the development of machine learning and computational solutions to resolve complex LC-HRMS-NTA data for environmental and biological studies. |
Michelle de Roo Function: PhD candidate |
||
PFAS in Soils and Sediments: Decoding speciation to develop predictive modeling
About the lecture Per- and polyfluoroalkyl substances (PFAS) are of increasing concern due to their ubiquitous presence and toxic effects on both human and ecological health. PFAS from soils and sediments can partition to pore water and be taken up by crops, endangering human health through food consumption, and can also migrate to groundwater polluting drinking water. Depending on the speciation, PFAS interaction at the soil-water interface differs owing to mineral surface properties and functional groups. In order to understand the fate and behavior of PFAS in soils and sediments, we aim to study PFAS speciation, i.e. the partitioning between their different chemical forms in the water and the solid phase. We have developed targeted extraction techniques to identify PFAS binding to various soil and organic matter fractions. Relating this binding preference to the PFAS speciation allows us to develop models to predict PFAS mobility and bioavailability in the given environment. Over the years, hundreds of different PFAS molecules have been produced that eventually make their way to the environment. The challenge in PFAS research lies in generally low environmental concentrations and correctly identifying the speciation. Further advances in analytics that help distinguish different PFAS speciation at low environmental concentration will be transformative in our understanding of PFAS fate and behavior in the environment.
About the speaker Michelle de Roo is a PhD candidate in the Soil Chemistry group at Wageningen University & Research. With a background in molecular and soil chemistry, her research on PFAS combines analytical chemistry with environmental science. She is developing targeted extraction techniques to identify and distinguish PFAS associated with different soil fractions. |
Wilco Nijenhuis Function: PhD candidate |
||
A Chemometric Approach to Improve Quantitation of Plastic Particles in Human Blood Using Non-Targeted Pyrolysis-GC-MS
About the lecture Accurate quantitative methods are crucial to assess human exposure to micro and nano plastics (MNPs). Quantitative pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) has recently been used to quantify MNPs in human blood. However, pyrolysis introduces complex effects, including potential secondary reactions between matrix compounds and polymers, which impact current quantification methods based on single markers. This study uses a chemometric approach to enhance the identification and quantification of MNPs in human blood. A non-targeted approach was used to investigate all thermal degradation products and study their behaviour. Blood samples spiked with MNPs were analysed to identify effective markers for various polymer types while addressing co-pyrolysis and matrix effects.
About the speaker I am a PhD candidate in the Analytical Chemistry for Environment group and Health at the Institute for Life and Environment (A-LIFE). My background is in analytical chemistry. My PhD research focuses on Machine Learning and High-Resolution Mass Spectrometry for Enhanced Environmental Contaminant Monitoring. The project aims to advance the identification and quantification of micro- and nanoplastic particles and the development of a workflow to assess spectral quality, enhancing predictive applications of environmental contaminants based on mass spectrometry. |
Analytical Solutions
Registratiewebsite voor Analytical SolutionsAnalytical Solutionsmarketing@aleapublishers.nl
Analytical Solutionsmarketing@aleapublishers.nlhttps://www.analyticalsolutions.nl
2024-05-28
2024-05-28
OfflineEventAttendanceMode
EventScheduled
Analytical SolutionsAnalytical Solutions0.00EUROnlineOnly2019-01-01T00:00:00Z
De ReeHorstDe ReeHorstBennekomseweg 24 6717 LM Ede Nederland