Tijmen S. Bos

Analytical Chemistry Group, Van ’t Hoff Institute for Molecular Sciences, University of Amsterdam

Deputy Head

Tijmen S. Bos is a dedicated researcher with expertise in advancing chromatographic systems and data analysis through automation and innovative methodologies. After earning his Ph.D. in 2023 from Vrije Universiteit Amsterdam, he joined the University of Amsterdam as a postdoctoral researcher. His work focuses on polymer analysis, where he develops state-of-the-art methods and algorithms to enhance separation techniques and extract deeper insights from analytical data. In addition to his role in Amsterdam, he is a guest researcher in Professor Dwight Stoll's group at Gustavus Adolphus College. His research is driven by a commitment to integrating cutting-edge advancements in automated method development into analytical science, contributing to both academic progress and practical applications.

Resolving Surface-Charge Density Distributions in Polymeric Nanoparticles Using CZE, HDC, and Chemometric Deconvolution

Understanding nanoparticle surface charge is crucial for optimizing their performance in industrial and biomedical applications. Using capillary zone electrophoresis (CZE) and hydrodynamic chromatography (HDC) with chemometric deconvolution, we resolved detailed surface charge density (SCD) distributions in polymeric nanoparticles. Our approach revealed size-dependent variations, multimodal charge populations, and the impact of surfactants on bare NP characterization.

Section title

Chemistry research that matters

The mission of the Van 't Hoff Institute for Molecular Sciences (HIMS) is to push the boundaries of chemistry by performing internationally recognized scientific research that is curiosity driven as well as application driven. HIMS strives at utilization and expansion of its knowledge and expertise by engaging in collaborative research efforts that address challenges in society and industry.

HIMS is one of eight research institutes of the Faculty of Science (FNWI) of the University of Amsterdam. HIMS houses around 200 researchers (145 fte) with over 30 nationalities. Together they publish around 200 peer reviewed scientific articles, 20 PhD theses and on average 4 patent applications per year.